I painted the bottom of my boat with Pettit Sandless Primer and Pettit Vivid blue bottom paint. Polyeurethane primers cure hard and smooth and have to be topcoated before fully cured. I applied the first coat of primer and only had to wait about 30 minutes before it was ready for the 2nd coat. Then, I put on the first coat of anti-fouling 30 minutes after finishing the 2nd coat of primer. The 2nd coat of anti-fouling went on the next day after the first coat had fully cured.
I sanded everything down by hand using a DA sander and 36 grit paper.