Nope, no problems at all. In fact, I believe that Bgreene has one on his V21 and loves it. 
I have a 200 HP Mercury on my V21 and will attest that it's perfect. I know a lot of people have 150's and 200's on their V20's and I've never heard anyone speak badly of them.
The only problem is when you shift to a 4 stroke engine and the extra weight that brings to the table.
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1987 V20 w/1987 150HP Yamaha on a Shoreland'r Trailer
1978 16.5 Airslot w/1996 120HP Force on a Four Winns trailer
1996 V21 w/1993 200HP Mercury on a Shoreline Trailer
All towed by a 5.7L Hemi Durango.
If God didn't have a purpose for us we wouldn't be here, so
Live simply, Love generously, Care deeply, Speak kindly.
(Leave the rest to God) 
Silence, in the face of evil, is itself evil. Not to speak is to speak, not to act is to act. God will not hold us guiltless.
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