No experience 2-stroke to 4-stroke but the weight difference between the two is what you are experiencing. My heavier 2-stroke motor on the bracket did throw up spray from the cav plate being buried too deep with the motor mounted at the same height of the lightweight 2-stroke. I do get the wake over the motor if you dump the throttle.. It wants to settle in the stern first and that is when the wave of water forms up motor high behind the boat. If I use some trim tab coming off plane it doesn't do it at all.
Raising the motor can solve the spray issue. Burp the throttle just before the wave gets to the motor coming off plane?