I agree with Phatdaddy.. put your wheel on first, so you get a better idea of how it will all go together. Then, just like Spareparts said, turn your saw down real slow and use a fine tooth blade. (24t should work fine). Lastly, when you are making square cutouts like that, use a 1/4" drill bit and drill 4 holes, one in each corner of the square before you cut the straight lines. The rounded edge of the hole will help keep the plexiglass from cracking at the corner. Also, if you can find it, I'd go with Lexan rather than Plexiglass... it's much, much stronger. (Also more expensive, but you get what you pay for) 
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1987 V20 w/1987 150HP Yamaha on a Shoreland'r Trailer
1978 16.5 Airslot w/1996 120HP Force on a Four Winns trailer
1996 V21 w/1993 200HP Mercury on a Shoreline Trailer
All towed by a 5.7L Hemi Durango.
If God didn't have a purpose for us we wouldn't be here, so
Live simply, Love generously, Care deeply, Speak kindly.
(Leave the rest to God) 
Silence, in the face of evil, is itself evil. Not to speak is to speak, not to act is to act. God will not hold us guiltless.
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