Without getting too technical, the max amps for wiring a chassis (Very very conservative figure ) for that wire is 181 amps. Your power drop, assuming a 20 foot run, 12 volts and 100 amp load would be about 0.32v or, put another way, the voltage would be 11.68 volts on the other end of the circuit. In careful engineering the voltage drop, insulation temperature limit, thickness, thermal conductivity, and air convection and temperature should all be taken into account but are not relative here.
To answer your question, the thicker the copper strands the more brittle and less flexible, but 2/0 AWG (American Wire Gauge) is still 2/0 AWG. Presuming both are copper there is no difference.
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1987 V20 w/1987 150HP Yamaha on a Shoreland'r Trailer
1978 16.5 Airslot w/1996 120HP Force on a Four Winns trailer
1996 V21 w/1993 200HP Mercury on a Shoreline Trailer
All towed by a 5.7L Hemi Durango.
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