i'm sure you'll get plenty of good ideas on the keys, but a place my family always enjoyed was st augustine. not sure if it would fit your driving schedule but might be a good midway point. there is a state park on the beach (anastasia, i think) and my kids love exploriing the old fort and the fountain of youth attraction. we went to the space center one year and did not enjoy it that much. lotta static displays and look but don't touch stuff and we had about 100 fifth graders ,so it was not too much fun for them. there is also a mock early settlement in st augustine that they also enjoyed.
sounds like a good trip'
enjoy
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