[willy]

Its a doable run, done it twice, once in my robalo 1820' cc and once in my friends 21 footer. Both times we had a weather window which said it would be good, we used the marine forecast taken at the outside buoys. In my robalo it got rough once the afternoon off shore winds kicked in but I just slowed down, in my friends boat which was a cuddy it was actually a little more worrisome to me due to it not being as seaworthy a hull as the robalo.
But both times it was just a run at cruise speed out and a little slower back in.
You just need to be prepared equipment wise as stated above, but in reality you should be that way whether you are running to the mudhole or running the bay. Biggest thing is good engine, reliable, extra everything for it, good life preservers, good working radio and a waterproof portable in a ditch bag along with all the other stuff like flares etc.
The best thing is to run it with a buddy boat or at least be in contact with a buddy out there if possible. I would like to do it but my V needs a good radio as it did not have one set up when I bought it and I have not been on it enough to need more than my good portable Icom.